Publications

Great Lakes NeuroTechnologies understands that clinical validation of new technologies is critical to demonstrating efficacy and safety as well as building product trust. Therefore, we have partnered with world-renowned movement disorder centers and neurologists to conduct clinical studies in several areas such as Parkinson’s disease and Essential tremor. Hundreds of patients have already successfully used our technologies for assessing movement disorders in clinical and home environments. The following highlights a subset of those clinical validation studies.

Peer-Reviewed Journal Articles

  1. Clinician Versus Machine: Reliability and Responsiveness of Motor Endpoints in Parkinson’s Disease
    D. Heldman, A. Espay, P. Lewitt, and J. Giuffrida
    Parkinsonism Relat Disord. 2014 Feb;22.
  2. Tremor retrainment as therapeutic strategy in psychogenic (functional) tremor
    A.J. Espay, M.J. Edwards, G.D. Oggioni, N. Phielipp, B. Cox, H. Gonzalez-Usigli, C. Pecina, D.A. Heldman, J. Mishra, A.E. Lang
    Parkinsonism Relat Disord. 2014.
  3. Continuous In-Home Monitoring Of Essential Tremor
    C. Pulliam, S. Eichenseer, C. Goetz, O. Waln, C. Hunter, J. Jankovic, D. Vaillancourt, J. Giuffrida, And D. Heldman
    Parkinsonism Relat Disord. 2014 Jan;20(1):37-40.
  4. Objective Motion Sensor Assessment Highly Correlated with Scores of Global Levodopa-Induced Dyskinesia in Parkinson’s Disease
    T. Mera, M. Burack, J. Giuffrida
    J Parkinsons Dis. 2013 Jan 1;3(3):399-407.
  5. Quantitative Analysis Of Gait And Balance Response To Deep Brain Stimulation In Parkinson’s Disease
    T. Mera, D. Filipkowski, D. Riley, C. Whitney, B. Walter, S. Gunzler, J. Giuffrida
    Gait & Posture. 2013 May;38(1):109-14
  6. Automated motion sensor quantification of gait and lower extremity bradykinesia
    D. Heldman, D. Filipkowski, R. Riley, C. Whitney, B. Walter, S. Gunzler, T. Mera
    Conf Proc IEEE Eng Med Biol Soc. 2012.
  7. Quantitative assessment of levodopa-induced dyskinesia using automated motion sensing technology
    T. Mera, M. Burack, J. Giuffrida
    Conf Proc IEEE Eng Med Biol Soc. 2012.
  8. Active-Assisted Cycling Improves Tremor and Bradykinesia in Parkinson’s Disease
    A. Ridgel, C. Peacock, E. Fickes, C. Kim
    Arch Phys Med Rehabil. 2012 Nov;93(11):2049-54
  9. Amplitude fluctuations in essential tremor
    G. Mostile, R. Fekete, J. Giuffrida, T. Yaltho, A. Davidson, A. Nicoletti, M. Zappia, J. Jankovic
    Parkinsonism Relat Disord. 2012 Aug;18(7):859-63
  10. Feasibility of Home-Based Automated Parkinson’s Disease Motor Assessment
    T. Mera, D. Heldman, A. Espay, M. Payne, J. Giuffrida
    J Neurosci Methods. 2012 Jan 15;203(1):152-6
  11. Differential Response of Speed, Amplitude, and Rhythm to Dopaminergic Medications in Parkinson’s Disease
    A. Espay, J. Giuffrida, R. Chen, M. Payne, F. Mazzella, E. Dunn, J. Vaughan, A. Duker, A. Sahay, S. Kim, F. Revilla, D. Heldman
    Mov Disord. 2011 Dec;26(14):2504-8
  12. Acute effects of passive leg cycling on upper extremity tremor and bradykinesia in Parkinson’s disease
    A. Ridgel, M. Muller, C. Kim, E. Fickes, T. Mera
    Phys Sportsmed. 2011 Sep;39(3):83-93
  13. The Modified Bradykinesia Rating Scale for Parkinson’s disease: Reliability and Comparison with Kinematic Measures
    D. Heldman, J. Giuffrida, R. Chen, M. Payne, F. Mazzella, A. Duker, A. Sahay, S. Kim, F. Revilla, A. Espay.
    Mov Disord. 2011 Aug 15;26(10):1859-63
  14. Essential Tremor Quantification During Activities of Daily Living
    D. Heldman, J. Jankovic, D. Vaillancourt, J. Prodoehl, R. Elble, J. Giuffrida
    Parkinsonism Relat Disord. 2011 Aug;17(7):537-42
  15. Kinematic Optimization of Deep Brain Stimulation Across Multiple Motor Symptoms in Parkinson’s Disease
    T. Mera, J. Vitek, J. Alberts, J. Giuffrida
    J Neurosci Methods. 2011 Jun 15;198(2):280-6
  16. Objective Measure of Upper Extremity Motor Impairment in Parkinsons Disease with Inertial Sensors
    J. Hoffman, J. McNames
    Conf Proc IEEE Eng Med Biol Soc. 2011;2011:4378-81
  17. Correlation between Kinesia system assessments and clinical tremor scores in patients with essential tremor
    M. Giovanni, J. Giuffrida, O. Adam, A. Davidson, J. Jankovic
    Mov Disord. 2010 Sep 15;25(12):1938-43
  18. Gender differences in onset timing and activation of the muscles of the dominant knee during stair climbing
    P. Sung, D. Lee
    Knee. 2009 Oct;16(5):375-80
  19. Clinically Deployable Kinesia Technology for Automated Tremor Assessment
    J. Giuffrida, D. Riley, B. Maddux, D. Heldman
    Mov Disord. 2009 Apr 15;24(5):723-30
  20. Upper-extremity stroke therapy task discrimination using motion sensors and electromyography
    J. Giuffrida, A. Lerner, R. Steiner, J. Daly
    IEEE Trans Neural Syst Rehabil Eng. 2008 Feb;16(1):82-90

Book Chapters

  1. Healthcare Sensor Networks: Challenges Toward Practical Implementation
    Chapter 10: Ambulatory and Remote Monitoring Of Parkinson’s Disease Motor Symptoms
    J. Giuffrida, E. Rapp

Presentations and Posters

  1. Quantifying Abnormal Muscle Tone Due To Neurological Impairment
    E. Brokaw
    Midwest American Society of Biomechanics Regional Meeting. Akron, Ohio. 2014
  2. Home-based Motion Sensor Monitoring for Parkinson’s Disease Clinical Trials
    D. Heldman, A. Espay, P. LeWitt, J. Giuffrida
    3rd World Parkinson Congress. Montreal, Canada, 2013
  3. Quantitative Motor Assessment of Gait and Lower Extremity Bradykinesia Following the Discontinuation of Deep Brain Stimulation
    T. Mera, D. Riley, B. Walter, A. Espay, F. Revilla, J. Giuffrida
    3rd World Parkinson Congress. Montreal, Canada, 2013
  4. Task-coupled dyskinesias in patients with Parkinson disease
    R. Unia, T. Mera, M. Burack
    3rd World Parkinson Congress. Montreal, Canada, 2013
  5. Bradykinesia and timed up and go are improved after dynamic cycling in Parkinson’s disease
    R. Phillips, K. Wilson, B. Walter, A. Ridgel
    3rd World Parkinson Congress. Montreal, Canada, 2013
  6. Test-Retest Reliability of a Parkinson’s Disease Monitoring System
    D. Heldman, A. Espay, P. LeWitt, J. Giuffrida
    17th International Congress of Parkinson’s Disease and Movement Disorders. Sydney, Australia, 2013
  7. Continuous home monitoring of essential tremor using motion sensors
    D. Heldman, C. Pulliam, S. Eichenseer, C. Goetz, O. Waln, C. Hunter, J. Jankovic, D. Vaillancourt, J. Giuffrida
    17th International Congress of Parkinson’s Disease and Movement Disorders. Sydney, Australia, 2013
  8. Deep brain stimulation programming in Parkinson’s disease using functional motor symptom response tuning maps
    T. Mera, J. Vitek, J. Giuffrida
    17th International Congress of Parkinson’s Disease and Movement Disorders. Sydney, Australia, 2013
  9. Tremor retrainment as therapeutic strategy for patients with psychogenic tremor: A proof-of-concept study
    A. Espay, G. Oggioni, M. Edwards, N. Phielipp, H. Gonzalez-Usigli, C. Pecina, D. Heldman, J. Mishra, A. Lang
    17th International Congress of Parkinson’s Disease and Movement Disorders. Sydney, Australia, 2013
  10. Effect of unilateral and bilateral STN stimulation and levodopa on distal and proximal alternating movement of the upper limb in Parkinson’s disease
    Radics P, Erőss L, Takáts A, Heldman D, Giuffrida J, Entz L, Fabó D, Tamás G
    International Conference on Deep Brain Stimulation. Dusseldorf, Germany, 2013
  11. Deep brain stimulation programming in PD using functional motor symptom response tuning maps
    T. Mera, Vitek J, J. Giuffrida
    International Conference on Deep Brain Stimulation. Dusseldorf, Germany, 2013
  12. Test-Retest Reliability of a Parkinson’s Disease Monitoring System
    Dustin Heldman, Alberto Espay, Peter LeWitt, and J. Giuffrida
    65th Annual Meeting of the American Academy of Neurology, San Diego, CA, 2013
  13. Continuous home monitoring of essential tremor using motion sensors
    C. Pulliam, S. Eichenseer, C. Goetz, O. Waln, C. Hunter, J. Jankovic, D. Vaillancourt, J. Giuffrida, and D. Heldman
    65th Annual Meeting of the American Academy of Neurology, San Diego, CA, 2013
  14. Deep brain stimulation programming in Parkinson’s disease using functional motor symptom response tuning maps
    T. Mera, J. Vitek, J. Giuffrida
    65th Annual Meeting of the American Academy of Neurology, San Diego, CA, 2013
  15. Patient Compliance with Parkinson’s Disease Home Monitoring System
    Danielle Filipkowski, Dustin Heldman, Alberto Espay, Jaya Mishra, Thomas Mera, and J. Giuffrida
    16th International Congress of Parkinson’s Disease and Movement Disorders, Dublin, Ireland 2012
  16. Capturing Choreatic Dyskinesia Over Levodopa Dose Cycle in Parkinson’s Disease
    T. Mera, Michelle Burack, MD, PhD, Frank Bonsignore, MS, J. Giuffrida, PhD
    16th International Congress of Parkinson’s Disease and Movement Disorders, Dublin, Ireland 2012
  17. Intra- and Multi-Day Home-Based Monitoring of Parkinson’s Disease Motor Symptoms
    D. Heldman, D. Filipkowski, A. Espay, Jaya Mishra,J. Giuffrida
    16th International Congress of Parkinson’s Disease and Movement Disorders, Dublin, Ireland 2012
  18. Patient Compliance with Parkinson’s Disease Home Monitoring System
    Danielle Filipkowski, Dustin Heldman, Alberto Espay, Jaya Mishra, Thomas Mera, and J. Giuffrida
    American Academy of Neurology 64th Annual Meeting, New Orleans, LA 2012
  19. Capturing Choreatic Dyskinesia Over Levodopa Dose Cycle in Parkinson’s Disease
    T. Mera, Michelle Burack, MD, PhD, Frank Bonsignore, MS, J. Giuffrida, PhD
    American Academy of Neurology 64th Annual Meeting, New Orleans, LA 2012
  20. Intra- and Multi-Day Home-Based Monitoring of Parkinson’s Disease Motor Symptoms
    D. Heldman, D. Filipkowski, A. Espay, Jaya Mishra,J. Giuffrida
    American Academy of Neurology 64th Annual Meeting, New Orleans, LA 2012
  21. Quantitative Home-Based Monitoring of Parkinson’s Disease Motor Symptoms
    D. Heldman, T. Mera, A. Espay, Payne M, J. Giuffrida
    International Congress of Parkinson’s Disease and Movement Disorders, Toronto, CA 2011
  22. Ergonomic and Human Interface Design Factors for Home-Based Medical devices in Movement Disorders
    D. Filipkowski, T. Mera, D. Heldman, J. Giuffrida
    International Congress of Parkinson’s Disease and Movement Disorders, Toronto, CA 2011
  23. Automated Parkinson’s Disease Gait and Balance Assessment for Optimization of Deep Brain Stimulation
    T. Mera, D. Filipkowski, Riley R, Walter B, Gunzler S, J. Giuffrida
    International Congress of Parkinson’s Disease and Movement Disorders, Toronto, CA 2011
  24. Amplitude Fluctuations in Essential Tremor: A Prospective Study
    Mostile G, Fekete R, J. Giuffrida, Yaltho T, Davidson A, Nicoletti A, Zappia M, J. Jankovic
    International Congress of Parkinson’s Disease and Movement Disorders, Toronto, CA 2011
  25. Logarithmic Relationship Between Head Tremor and 5-Point Tremor Rating
    Rodger Elble, MD PhD, Helge Hellriegel, MD, Jan Raethjen, MD and Günther Deuschl, MD
  26. Automated Optimization of Deep Brain Stimulation Settings across Multiple Parkinson’s Disease Motor Symptoms
    Joseph P. Giuffrida, Jay L. Alberts, Jerrold Vitek, T. Mera
    Presented at the 2010 American Academy of Neurology Annual Meeting
  27. Differential Response of Speed, Amplitude, and Rhythm to Dopaminergic Medications in Parkinson’s Disease
    A. Espay, D. Heldman, Robert Chen, Sang-jin Kim, Jennifer E. Vaughan, Emily Dunn, Andrew P. Duker,J. Giuffrida
    Presented at the 2010 American Academy of Neurology Annual Meeting
  28. Differential Response of Bradykinesia and Hypokinesia to Levodopa in Parkinson’s Disease
    A. Espay,J. Giuffrida, Robert Chen, Jennifer E. Vaughan, Andrew P. Duker, D. Heldman
    Presented at the 2009 World Federation of Neurology World Congress on Parkinson’s Disease and Related Disorders
  29. ParkinTune: Automated Parkinson’s Disease Motor Assessment for DBS Programming
    T. Mera, MS, Jerrold Vitek, MD, PhD, Jay Alberts, PhD,J. Giuffrida
    Presented by the 2009 World Federation of Neurology World Congress on Parkinson’s Disease and Related Disorders
  30. Automated Parkinson’s Disease Motor Assessment for Clinical and Ambulatory Monitoring
    D. Heldman, Ph.D., A. Espay, M.D., Peter LeWitt, M.D.,J. Giuffrida, Ph.D.
    Presented by the 2009 World Federation of Neurology World Congress on Parkinson’s Disease and Related Disorders
  31. Effects of Pedaling Rate on Upper Extremity Motor Improvements During Passive Leg Cycling in Parkinson’s Disease
    A.L. Ridgel, M.D. Muller, C-H. Kim, E.J. Fickes, K. Wilson, T. Mera and J. L. Alberts
    Presented at the 2009 Society for Neuroscience Annual Meeting
  32. Correlation between Kinesia System Assessments and Clinical TETRAS Scores in Patients with Essential Tremor
    Giovanni Mostile, MD,J. Giuffrida, PhD, Octavian R. Adam, MD, Anthony Davidson, BS, Joseph Jankovic, MD
    Presented at the 2009 13th International Congress of Parkinson’s Disease and Movement Disorders
  33. Correlation Between Clinical Rating of Parkinsonian and Essential Tremor and Quantitative Assessments
    L. Giselle Aguilar, M.D.,J. Giuffrida, Ph.D., D. Heldman, Ph.D., Joseph Jankovic, M.D.
    Presented at the 2008 12th International Congress of Parkinson’s Disease and Movement Disorders
  34. Kinematic Akinesia Feature Extraction Using Kinesia
    D. Heldman, Ph.D., David E. Riley, M.D., Brian N. Maddux, M.D., Ph.D.,J. Giuffrida, Ph.D.
    Presented at the 2008 12th International Congress of Parkinson’s Disease and Movement Disorders
  35. Comparison of Kinesia to the Unified Parkinson’s Disease Rating Scale: Tremor and Bradykinesia Results
    D. Heldman, Ph.D., David E. Riley, M.D., Brian N. Maddux, M.D., Ph.D.,J. Giuffrida, Ph.D.
    Presented at the 2008 American Academy of Neurology Annual Meeting

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Great Lakes NeuroTechnologies is committed to pioneering innovative biomedical technologies to serve research, education and medical communities, improving access to medical technology for diverse populations, and positively impacting quality of life for people around the world.